I-30: Prevalence of Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Background: Metabolic syndrome is a disorder which is composed of several metabolic abnormalities: glucose intolerance, dyslipidemia, obesity and hypertension. PCOS which is characterized by menstrual irregularities and hyperandrogenism, is a common endocrinological disorder in female reproductive age. The prevalence of the syndrome is 5-10%. Insulin resistance is a common feature of the PCOS (60-65%), both obese and nonobese women. Insulin resistance and hyperinsulinemia are also the important pathophysiology of MS. Recent data have shown that the prevalence of MS among PCOS women is 43-46%, which is higher than that reported for age-matched women from the general population. The aim of the present study was to determine the prevalence of MS in Iranian women with PCOS using the NCEP-ATPIII criteria. Materials and Methods: This cross-sectional study was conducted in 2012. 624 women with PCOS who consecutively attended the reproductive endocrinology and infertility unit of Royan institute were enrolled in this study. The rotterdom criteria was used for the diagnosis of PCOS. Women aged>40 and who used contraceptive drugs at 3 months prior the study, excluded from the study. NCEP ATPIII criteria for DX of MS: 3 of the following disorders: 1- hypertension: BP≥130 mm/hg and/or current antihypertensive therapy. 2-dyslipidemia: triglyceride level≥150 mg/dl and/or HDL level<50 mg/dl. 3-obesity: waist circumference≥88cm. 4-FBS≥100mg/dl. Results: The prevalence of MS (3 criteria) was 19.7%. 1/5 of PCOS patients had abnormal glucose metabolism. Dyslipidemia is the most frequent metabolic disorder in PCOS patients (>70%). Conclusion: Metabolic syndrome was no more frequent in Iranian infertile PCOS patients than in Iranian normal population.